Side-by-Side Comparison · 2026

5-Amino-1MQ vs AOD-9604

5-Amino-1MQ vs AOD-9604 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

5-Amino-1MQ
Metabolic & Mitochondrial

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that regulates NAD+ metabolism and energy expenditure in adipose tissue. By blocking NNMT, 5-Amino-1MQ raises intracellular NAD+ and SAM levels, pushing stem cells toward muscle and bo...

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AOD-9604
Metabolic & Mitochondrial

AOD-9604 (Anti-Obesity Drug 9604) is a synthetic fragment of human growth hormone (hGH), specifically the C-terminal region spanning amino acids 176-191 with an additional tyrosine at position 177. It was designed to isolate the fat-metabolizing properties of hGH without the IGF-...

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Key Parameters
Parameter 5-Amino-1MQ AOD-9604
Category Metabolic & Mitochondrial Metabolic & Mitochondrial
Research Preclinical Phase IIb (Discontinued)
Half-Life ~4 hours (estimated) ~30 minutes
Typical Dose 50 mg 300 µg
Frequency Once daily Once daily (fasted)
Route Oral Subcutaneous / Oral
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between 5-Amino-1MQ and AOD-9604?
5-Amino-1MQ: 5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that regulates NAD+ metabolism and energy expenditure in adipose tissue. By blocking NNMT, 5-Amino-1MQ r... AOD-9604: AOD-9604 (Anti-Obesity Drug 9604) is a synthetic fragment of human growth hormone (hGH), specifically the C-terminal region spanning amino acids 176-191 with an additional tyrosine at position 177. It...
Which has a longer half-life, 5-Amino-1MQ or AOD-9604?
5-Amino-1MQ half-life: ~4 hours (estimated). AOD-9604 half-life: ~30 minutes.
Can you stack 5-Amino-1MQ and AOD-9604?
5-Amino-1MQ and AOD-9604 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.