Side-by-Side Comparison · 2026

Adamax vs PE-22-28

Adamax vs PE-22-28 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Adamax
Cognitive & Neurological

Adamax is a branded formulation of N-Acetyl Semax Amidate, the most potent and longest-acting analog of the nootropic peptide Semax. The N-acetyl modification at the N-terminus and amide modification at the C-terminus together extend its half-life and increase BDNF-stimulating po...

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PE-22-28
Cognitive & Neurological

PE-22-28 is a synthetic fragment of spadin (a naturally occurring peptide derived from the NTSR3/sortilin propeptide) that antagonizes TREK-1, a two-pore domain potassium channel (K2P channel) that regulates neuronal excitability. TREK-1 is strongly implicated in depression and c...

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Key Parameters
Parameter Adamax PE-22-28
Category Cognitive & Neurological Cognitive & Neurological
Research Research Use Preclinical
Half-Life ~8–12 hours (extended vs. standard Semax) -
Typical Dose 100–300 µg 100–200 µg
Frequency Once or twice daily Daily
Route Intranasal Subcutaneous / Intranasal
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between Adamax and PE-22-28?
Adamax: Adamax is a branded formulation of N-Acetyl Semax Amidate, the most potent and longest-acting analog of the nootropic peptide Semax. The N-acetyl modification at the N-terminus and amide modification ... PE-22-28: PE-22-28 is a synthetic fragment of spadin (a naturally occurring peptide derived from the NTSR3/sortilin propeptide) that antagonizes TREK-1, a two-pore domain potassium channel (K2P channel) that re...
Which has a longer half-life, Adamax or PE-22-28?
Adamax half-life: ~8–12 hours (extended vs. standard Semax). PE-22-28 half-life: unknown.
Can you stack Adamax and PE-22-28?
Adamax and PE-22-28 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.