Side-by-Side Comparison · 2026

Adrenomedullin vs Apelin-13

Adrenomedullin vs Apelin-13 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Adrenomedullin
Cardiovascular Peptide

Adrenomedullin (ADM) is a 52-amino acid vasoactive peptide first isolated from human pheochromocytoma tissue in 1993. It is now recognized as a pleiotropic hormone produced widely throughout the body, with highest expression in the adrenal medulla, heart, lung, kidney, and vascul...

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Apelin-13
Cardiovascular Peptide

Apelin-13 is the most biologically active isoform of the apelin peptide family, endogenous ligands for the APJ receptor (also called APLNR). Apelin peptides are produced throughout the body, with the heart, lung, brain, and adipose tissue expressing particularly high levels....

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Key Parameters
Parameter Adrenomedullin Apelin-13
Category Cardiovascular Peptide Cardiovascular Peptide
Research Clinical Clinical
Half-Life 22 min (plasma) < 5 min (plasma)
Typical Dose 2-10 ng/kg/min (IV infusion) 50-300 nmol/kg
Frequency Acute infusion or short course Variable
Route Intravenous, Subcutaneous Intravenous (research), Subcutaneous
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Adrenomedullin and Apelin-13?
Adrenomedullin: Adrenomedullin (ADM) is a 52-amino acid vasoactive peptide first isolated from human pheochromocytoma tissue in 1993. It is now recognized as a pleiotropic hormone produced widely throughout the body,... Apelin-13: Apelin-13 is the most biologically active isoform of the apelin peptide family, endogenous ligands for the APJ receptor (also called APLNR). Apelin peptides are produced throughout the body, with the ...
Which has a longer half-life, Adrenomedullin or Apelin-13?
Adrenomedullin half-life: 22 min (plasma). Apelin-13 half-life: < 5 min (plasma).
Can you stack Adrenomedullin and Apelin-13?
Adrenomedullin and Apelin-13 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.