Side-by-Side Comparison · 2026

Adrenomedullin vs Apelin-17

Adrenomedullin vs Apelin-17 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Adrenomedullin
Cardiovascular Peptide

Adrenomedullin (ADM) is a 52-amino acid vasoactive peptide first isolated from human pheochromocytoma tissue in 1993. It is now recognized as a pleiotropic hormone produced widely throughout the body, with highest expression in the adrenal medulla, heart, lung, kidney, and vascul...

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Apelin-17
Cardiovascular Peptide

Apelin-17 is a 17-amino acid C-terminal fragment of the prepro-apelin precursor that binds and activates the APJ receptor (now APLNR) with the highest potency of all naturally occurring apelin isoforms. While apelin-13 is the best-characterized isoform, apelin-17 shows greater re...

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Key Parameters
Parameter Adrenomedullin Apelin-17
Category Cardiovascular Peptide Cardiovascular Peptide
Research Clinical Preclinical / Phase I
Half-Life 22 min (plasma) ~3-5 minutes IV (longer than apelin-13)
Typical Dose 2-10 ng/kg/min (IV infusion) 30-100 nmol/kg/min (IV infusion, clinical)
Frequency Acute infusion or short course Acute infusion protocols
Route Intravenous, Subcutaneous IV infusion (clinical studies); SC under investigation
FDA Status Not approved Investigational (Phase I/II)

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Frequently Asked Questions
What is the difference between Adrenomedullin and Apelin-17?
Adrenomedullin: Adrenomedullin (ADM) is a 52-amino acid vasoactive peptide first isolated from human pheochromocytoma tissue in 1993. It is now recognized as a pleiotropic hormone produced widely throughout the body,... Apelin-17: Apelin-17 is a 17-amino acid C-terminal fragment of the prepro-apelin precursor that binds and activates the APJ receptor (now APLNR) with the highest potency of all naturally occurring apelin isoform...
Which has a longer half-life, Adrenomedullin or Apelin-17?
Adrenomedullin half-life: 22 min (plasma). Apelin-17 half-life: ~3-5 minutes IV (longer than apelin-13).
Can you stack Adrenomedullin and Apelin-17?
Adrenomedullin and Apelin-17 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.