Side-by-Side Comparison · 2026

Adrenomedullin vs Catestatin

Adrenomedullin vs Catestatin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Adrenomedullin
Cardiovascular Peptide

Adrenomedullin (ADM) is a 52-amino acid vasoactive peptide first isolated from human pheochromocytoma tissue in 1993. It is now recognized as a pleiotropic hormone produced widely throughout the body, with highest expression in the adrenal medulla, heart, lung, kidney, and vascul...

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Catestatin
Cardiovascular Peptide

Catestatin is a 21-amino acid peptide derived from the chromogranin A (CgA) protein, specifically cleaved from the region spanning residues 352-372. It was identified as an endogenous inhibitor of catecholamine secretion, acting as a non-competitive antagonist at nicotinic acetyl...

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Key Parameters
Parameter Adrenomedullin Catestatin
Category Cardiovascular Peptide Cardiovascular Peptide
Research Clinical Preclinical / Early Human
Half-Life 22 min (plasma) ~15-30 minutes (IV)
Typical Dose 2-10 ng/kg/min (IV infusion) 0.3-3 nmol/kg (animal studies)
Frequency Acute infusion or short course Acute dosing in research
Route Intravenous, Subcutaneous IV (research); intranasal under study
FDA Status Not approved Research compound

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Frequently Asked Questions
What is the difference between Adrenomedullin and Catestatin?
Adrenomedullin: Adrenomedullin (ADM) is a 52-amino acid vasoactive peptide first isolated from human pheochromocytoma tissue in 1993. It is now recognized as a pleiotropic hormone produced widely throughout the body,... Catestatin: Catestatin is a 21-amino acid peptide derived from the chromogranin A (CgA) protein, specifically cleaved from the region spanning residues 352-372. It was identified as an endogenous inhibitor of cat...
Which has a longer half-life, Adrenomedullin or Catestatin?
Adrenomedullin half-life: 22 min (plasma). Catestatin half-life: ~15-30 minutes (IV).
Can you stack Adrenomedullin and Catestatin?
Adrenomedullin and Catestatin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.