Side-by-Side Comparison · 2026

Adrenomedullin vs Elabela

Adrenomedullin vs Elabela — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Adrenomedullin
Cardiovascular Peptide

Adrenomedullin (ADM) is a 52-amino acid vasoactive peptide first isolated from human pheochromocytoma tissue in 1993. It is now recognized as a pleiotropic hormone produced widely throughout the body, with highest expression in the adrenal medulla, heart, lung, kidney, and vascul...

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Elabela
Cardiovascular Peptide

Elabela (also called Apela or Toddler) is the second endogenous peptide ligand for the APJ receptor, discovered in 2013 independently through two approaches: as an essential zebrafish cardiac development factor (Toddler) and as a novel human APJ ligand (Elabela). Unlike apelin pe...

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Key Parameters
Parameter Adrenomedullin Elabela
Category Cardiovascular Peptide Cardiovascular Peptide
Research Clinical Research
Half-Life 22 min (plasma) Short (minutes, estimated)
Typical Dose 2-10 ng/kg/min (IV infusion) 5-500 nmol/kg (animal)
Frequency Acute infusion or short course Variable
Route Intravenous, Subcutaneous Subcutaneous, Intravenous
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Adrenomedullin and Elabela?
Adrenomedullin: Adrenomedullin (ADM) is a 52-amino acid vasoactive peptide first isolated from human pheochromocytoma tissue in 1993. It is now recognized as a pleiotropic hormone produced widely throughout the body,... Elabela: Elabela (also called Apela or Toddler) is the second endogenous peptide ligand for the APJ receptor, discovered in 2013 independently through two approaches: as an essential zebrafish cardiac developm...
Which has a longer half-life, Adrenomedullin or Elabela?
Adrenomedullin half-life: 22 min (plasma). Elabela half-life: Short (minutes, estimated).
Can you stack Adrenomedullin and Elabela?
Adrenomedullin and Elabela are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.