Side-by-Side Comparison · 2026

Adrenomedullin vs Intermedin

Adrenomedullin vs Intermedin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Adrenomedullin
Cardiovascular Peptide

Adrenomedullin (ADM) is a 52-amino acid vasoactive peptide first isolated from human pheochromocytoma tissue in 1993. It is now recognized as a pleiotropic hormone produced widely throughout the body, with highest expression in the adrenal medulla, heart, lung, kidney, and vascul...

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Intermedin
Cardiovascular Peptide

Intermedin (also called Adrenomedullin 2, AM2) is a 47-53 amino acid peptide belonging to the calcitonin gene-related peptide (CGRP)/adrenomedullin superfamily. Discovered in 2004, intermedin is widely expressed in the heart, lung, kidney, gut, and brain....

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Key Parameters
Parameter Adrenomedullin Intermedin
Category Cardiovascular Peptide Cardiovascular Peptide
Research Clinical Preclinical Research
Half-Life 22 min (plasma) ~15-30 minutes
Typical Dose 2-10 ng/kg/min (IV infusion) 1-100 pmol/kg/min infusion (animal)
Frequency Acute infusion or short course Acute infusion
Route Intravenous, Subcutaneous IV (research); SC in some studies
FDA Status Not approved Research compound

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Frequently Asked Questions
What is the difference between Adrenomedullin and Intermedin?
Adrenomedullin: Adrenomedullin (ADM) is a 52-amino acid vasoactive peptide first isolated from human pheochromocytoma tissue in 1993. It is now recognized as a pleiotropic hormone produced widely throughout the body,... Intermedin: Intermedin (also called Adrenomedullin 2, AM2) is a 47-53 amino acid peptide belonging to the calcitonin gene-related peptide (CGRP)/adrenomedullin superfamily. Discovered in 2004, intermedin is widel...
Which has a longer half-life, Adrenomedullin or Intermedin?
Adrenomedullin half-life: 22 min (plasma). Intermedin half-life: ~15-30 minutes.
Can you stack Adrenomedullin and Intermedin?
Adrenomedullin and Intermedin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.