Side-by-Side Comparison · 2026

AHK-Cu vs Melanotan II

AHK-Cu vs Melanotan II — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

AHK-Cu
Skin & Cosmetic

AHK-Cu is a copper-chelating tripeptide (Ala-His-Lys) that functions as a hair follicle stimulant and skin regeneration signal. Related to the more widely studied GHK-Cu, AHK-Cu has shown specific activity in promoting hair follicle stem cell proliferation and inhibiting DHT-rela...

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Melanotan II
Skin & Cosmetic

Melanotan II (MT-II) is a synthetic analog of alpha-MSH (alpha-melanocyte-stimulating hormone) that non-selectively activates melanocortin receptors MC1R through MC5R. It produces accelerated skin tanning via MC1R stimulation of melanogenesis, increases libido through MC3R and MC...

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Key Parameters
Parameter AHK-Cu Melanotan II
Category Skin & Cosmetic Skin & Cosmetic
Research Research Use Research Use
Half-Life - ~1.5 hours
Typical Dose 2–5% solution 250–500 µg (starting); up to 1,000 µg
Frequency Once or twice daily Daily initially; 2–3x/week maintenance
Route Topical Subcutaneous
FDA Status Not Approved (Cosmetic) Not Approved

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Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

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Frequently Asked Questions
What is the difference between AHK-Cu and Melanotan II?
AHK-Cu: AHK-Cu is a copper-chelating tripeptide (Ala-His-Lys) that functions as a hair follicle stimulant and skin regeneration signal. Related to the more widely studied GHK-Cu, AHK-Cu has shown specific act... Melanotan II: Melanotan II (MT-II) is a synthetic analog of alpha-MSH (alpha-melanocyte-stimulating hormone) that non-selectively activates melanocortin receptors MC1R through MC5R. It produces accelerated skin tan...
Which has a longer half-life, AHK-Cu or Melanotan II?
AHK-Cu half-life: unknown. Melanotan II half-life: ~1.5 hours.
Can you stack AHK-Cu and Melanotan II?
AHK-Cu and Melanotan II are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.