Side-by-Side Comparison · 2026

Alamethicin vs Bacitracin

Alamethicin vs Bacitracin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Alamethicin
Antimicrobial Peptide

Alamethicin is a 20-residue peptaibol (peptide with a high proportion of alpha-aminoisobutyric acid, Aib) from the fungus Trichoderma viride. It is the prototypical voltage-gated peptide ion channel, forming multi-state conductance channels in lipid bilayers whose opening probabi...

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Bacitracin
Antimicrobial Peptide

Bacitracin is a polycyclic peptide antibiotic from Bacillus subtilis licheniformis, first isolated in 1945 from wound cultures of a 7-year-old girl named Margaret Tracy (hence "bacitracin"). It is available OTC in Neosporin and similar triple-antibiotic ointments and is one of th...

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Key Parameters
Parameter Alamethicin Bacitracin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical (research tool) FDA Approved (topical)
Half-Life Membrane-stable Hours (topical)
Typical Dose N/A 400-500 units/g ointment
Frequency N/A 1-3x daily
Route Research only Topical
FDA Status Not approved Approved (topical)

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Frequently Asked Questions
What is the difference between Alamethicin and Bacitracin?
Alamethicin: Alamethicin is a 20-residue peptaibol (peptide with a high proportion of alpha-aminoisobutyric acid, Aib) from the fungus Trichoderma viride. It is the prototypical voltage-gated peptide ion channel, ... Bacitracin: Bacitracin is a polycyclic peptide antibiotic from Bacillus subtilis licheniformis, first isolated in 1945 from wound cultures of a 7-year-old girl named Margaret Tracy (hence "bacitracin"). It is ava...
Which has a longer half-life, Alamethicin or Bacitracin?
Alamethicin half-life: Membrane-stable. Bacitracin half-life: Hours (topical).
Can you stack Alamethicin and Bacitracin?
Alamethicin and Bacitracin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.