Side-by-Side Comparison · 2026

Alamethicin vs Gramicidin A

Alamethicin vs Gramicidin A — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Alamethicin
Antimicrobial Peptide

Alamethicin is a 20-residue peptaibol (peptide with a high proportion of alpha-aminoisobutyric acid, Aib) from the fungus Trichoderma viride. It is the prototypical voltage-gated peptide ion channel, forming multi-state conductance channels in lipid bilayers whose opening probabi...

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Gramicidin A
Antimicrobial Peptide

Gramicidin A is a 15-residue linear peptide antibiotic from Bacillus brevis, distinct from the cyclic gramicidin S despite sharing the same producer organism. Gramicidin A is the active component in Neosporin and other topical antibiotic combinations....

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Key Parameters
Parameter Alamethicin Gramicidin A
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical (research tool) Approved (topical combination)
Half-Life Membrane-stable Hours (membrane-bound)
Typical Dose N/A Component of Neosporin and similar products
Frequency N/A As needed
Route Research only Topical (combination products)
FDA Status Not approved Approved (topical combination)

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Frequently Asked Questions
What is the difference between Alamethicin and Gramicidin A?
Alamethicin: Alamethicin is a 20-residue peptaibol (peptide with a high proportion of alpha-aminoisobutyric acid, Aib) from the fungus Trichoderma viride. It is the prototypical voltage-gated peptide ion channel, ... Gramicidin A: Gramicidin A is a 15-residue linear peptide antibiotic from Bacillus brevis, distinct from the cyclic gramicidin S despite sharing the same producer organism. Gramicidin A is the active component in N...
Which has a longer half-life, Alamethicin or Gramicidin A?
Alamethicin half-life: Membrane-stable. Gramicidin A half-life: Hours (membrane-bound).
Can you stack Alamethicin and Gramicidin A?
Alamethicin and Gramicidin A are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.