Side-by-Side Comparison · 2026

Alamethicin vs Gramicidin S

Alamethicin vs Gramicidin S — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Alamethicin
Antimicrobial Peptide

Alamethicin is a 20-residue peptaibol (peptide with a high proportion of alpha-aminoisobutyric acid, Aib) from the fungus Trichoderma viride. It is the prototypical voltage-gated peptide ion channel, forming multi-state conductance channels in lipid bilayers whose opening probabi...

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Gramicidin S
Antimicrobial Peptide

Gramicidin S (Soviet gramicidin) is a cyclic decapeptide antibiotic discovered in 1942 by Soviet scientists Gause and Brazhnikova from Bacillus brevis, during World War II. It became a frontline topical wound antiseptic for Soviet forces....

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Key Parameters
Parameter Alamethicin Gramicidin S
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical (research tool) Approved (topical, certain countries)
Half-Life Membrane-stable Hours (topical)
Typical Dose N/A 0.1-0.5% in topical preparations
Frequency N/A As needed
Route Research only Topical
FDA Status Not approved Not FDA approved (approved in USSR/Russia, used in Europe)

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Frequently Asked Questions
What is the difference between Alamethicin and Gramicidin S?
Alamethicin: Alamethicin is a 20-residue peptaibol (peptide with a high proportion of alpha-aminoisobutyric acid, Aib) from the fungus Trichoderma viride. It is the prototypical voltage-gated peptide ion channel, ... Gramicidin S: Gramicidin S (Soviet gramicidin) is a cyclic decapeptide antibiotic discovered in 1942 by Soviet scientists Gause and Brazhnikova from Bacillus brevis, during World War II. It became a frontline topic...
Which has a longer half-life, Alamethicin or Gramicidin S?
Alamethicin half-life: Membrane-stable. Gramicidin S half-life: Hours (topical).
Can you stack Alamethicin and Gramicidin S?
Alamethicin and Gramicidin S are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.