Side-by-Side Comparison · 2026

Alamethicin vs Polymyxin B

Alamethicin vs Polymyxin B — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Alamethicin
Antimicrobial Peptide

Alamethicin is a 20-residue peptaibol (peptide with a high proportion of alpha-aminoisobutyric acid, Aib) from the fungus Trichoderma viride. It is the prototypical voltage-gated peptide ion channel, forming multi-state conductance channels in lipid bilayers whose opening probabi...

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Polymyxin B
Antimicrobial Peptide

Polymyxin B is a cyclic lipopeptide antibiotic from Bacillus polymyxa that was approved in the 1960s and fell out of favor due to nephrotoxicity, but has experienced a major clinical resurgence as a last-resort treatment for carbapenem-resistant Gram-negative infections (Acinetob...

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Key Parameters
Parameter Alamethicin Polymyxin B
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical (research tool) FDA Approved
Half-Life Membrane-stable 6-8 hours
Typical Dose N/A 15,000-25,000 units/kg/day IV
Frequency N/A Every 12 hours IV
Route Research only IV / IM / Topical / Intrathecal
FDA Status Not approved Approved (systemic Gram-negative infections)

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Frequently Asked Questions
What is the difference between Alamethicin and Polymyxin B?
Alamethicin: Alamethicin is a 20-residue peptaibol (peptide with a high proportion of alpha-aminoisobutyric acid, Aib) from the fungus Trichoderma viride. It is the prototypical voltage-gated peptide ion channel, ... Polymyxin B: Polymyxin B is a cyclic lipopeptide antibiotic from Bacillus polymyxa that was approved in the 1960s and fell out of favor due to nephrotoxicity, but has experienced a major clinical resurgence as a l...
Which has a longer half-life, Alamethicin or Polymyxin B?
Alamethicin half-life: Membrane-stable. Polymyxin B half-life: 6-8 hours.
Can you stack Alamethicin and Polymyxin B?
Alamethicin and Polymyxin B are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.