Side-by-Side Comparison · 2026

Alamethicin vs Protegrin-1

Alamethicin vs Protegrin-1 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Alamethicin
Antimicrobial Peptide

Alamethicin is a 20-residue peptaibol (peptide with a high proportion of alpha-aminoisobutyric acid, Aib) from the fungus Trichoderma viride. It is the prototypical voltage-gated peptide ion channel, forming multi-state conductance channels in lipid bilayers whose opening probabi...

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Protegrin-1
Antimicrobial Peptide

Protegrin-1 (PG-1) is an 18-residue cationic beta-hairpin antimicrobial peptide isolated from porcine leukocytes. It is stabilized by two intramolecular disulfide bonds that lock its hairpin conformation....

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Key Parameters
Parameter Alamethicin Protegrin-1
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical (research tool) Phase 3 / Clinical
Half-Life Membrane-stable Short
Typical Dose N/A 0.1-1 mg/mL (topical)
Frequency N/A BID-TID
Route Research only Topical / Oral rinse (research)
FDA Status Not approved Phase 3 clinical evaluation (iseganan)

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Frequently Asked Questions
What is the difference between Alamethicin and Protegrin-1?
Alamethicin: Alamethicin is a 20-residue peptaibol (peptide with a high proportion of alpha-aminoisobutyric acid, Aib) from the fungus Trichoderma viride. It is the prototypical voltage-gated peptide ion channel, ... Protegrin-1: Protegrin-1 (PG-1) is an 18-residue cationic beta-hairpin antimicrobial peptide isolated from porcine leukocytes. It is stabilized by two intramolecular disulfide bonds that lock its hairpin conformat...
Which has a longer half-life, Alamethicin or Protegrin-1?
Alamethicin half-life: Membrane-stable. Protegrin-1 half-life: Short.
Can you stack Alamethicin and Protegrin-1?
Alamethicin and Protegrin-1 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.