Side-by-Side Comparison · 2026

Angiotensin 1-9 vs Relaxin-2

Angiotensin 1-9 vs Relaxin-2 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Angiotensin 1-9
Cardiovascular Peptide

Angiotensin 1-9 (Ang 1-9) is a 9-amino acid peptide formed when ACE2 cleaves the C-terminal leucine from angiotensin I (Ang I, 10 AA). Discovered as part of the counter-regulatory renin-angiotensin system (RAS), Ang 1-9 opposes the hypertensive and tissue-damaging actions of angi...

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Relaxin-2
Cardiovascular Peptide

Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tissue remodeling. Beyond reproduction, relaxin-2 is a systemic anti-fibrotic and v...

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Key Parameters
Parameter Angiotensin 1-9 Relaxin-2
Category Cardiovascular Peptide Cardiovascular Peptide
Research Preclinical Research Clinical
Half-Life ~20-30 minutes 10-15 min (plasma)
Typical Dose 40-400 ng/kg/min IV infusion (animal) 30-300 mcg/kg/day (IV)
Frequency Acute infusion protocols Continuous 48-hour infusion (trials)
Route IV/SC (research) Intravenous (infusion)
FDA Status Research compound Not approved (Phase III completed)

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Frequently Asked Questions
What is the difference between Angiotensin 1-9 and Relaxin-2?
Angiotensin 1-9: Angiotensin 1-9 (Ang 1-9) is a 9-amino acid peptide formed when ACE2 cleaves the C-terminal leucine from angiotensin I (Ang I, 10 AA). Discovered as part of the counter-regulatory renin-angiotensin sy... Relaxin-2: Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tis...
Which has a longer half-life, Angiotensin 1-9 or Relaxin-2?
Angiotensin 1-9 half-life: ~20-30 minutes. Relaxin-2 half-life: 10-15 min (plasma).
Can you stack Angiotensin 1-9 and Relaxin-2?
Angiotensin 1-9 and Relaxin-2 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.