Side-by-Side Comparison · 2026

Angiotensin II vs Urotensin-II

Angiotensin II vs Urotensin-II — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Angiotensin II
Vasoactive Peptide

Angiotensin II is the principal effector peptide of the renin-angiotensin-aldosterone system (RAAS), a master regulator of blood pressure, fluid balance, and cardiovascular function. Generated by sequential cleavage of angiotensinogen by renin (producing Ang I) then by angiotensi...

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Urotensin-II
Vasoactive Peptide

Human Urotensin-II (U-II) is an 11-amino acid cyclic peptide and the most potent mammalian vasoconstrictor identified to date - approximately 10 to 20 times more potent than endothelin-1 in isolated vascular preparations. Originally characterized in fish urophysis (caudal neurose...

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Key Parameters
Parameter Angiotensin II Urotensin-II
Category Vasoactive Peptide Vasoactive Peptide
Research Clinical Active Research
Half-Life 30 seconds - 2 minutes (plasma) ~30 minutes (plasma)
Typical Dose 20-40 ng/kg/min (vasopressor) 0.01-1 nmol/kg/min IV (animal); picomolar concentrations produce vasoconstriction
Frequency Continuous infusion in clinical use Acute infusion
Route Intravenous (continuous infusion) IV infusion (research/clinical studies)
FDA Status Approved (Giapreza, vasodilatory shock) Research compound; UT receptor antagonists in clinical trials

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Frequently Asked Questions
What is the difference between Angiotensin II and Urotensin-II?
Angiotensin II: Angiotensin II is the principal effector peptide of the renin-angiotensin-aldosterone system (RAAS), a master regulator of blood pressure, fluid balance, and cardiovascular function. Generated by sequ... Urotensin-II: Human Urotensin-II (U-II) is an 11-amino acid cyclic peptide and the most potent mammalian vasoconstrictor identified to date - approximately 10 to 20 times more potent than endothelin-1 in isolated v...
Which has a longer half-life, Angiotensin II or Urotensin-II?
Angiotensin II half-life: 30 seconds - 2 minutes (plasma). Urotensin-II half-life: ~30 minutes (plasma).
Can you stack Angiotensin II and Urotensin-II?
Angiotensin II and Urotensin-II are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.