Side-by-Side Comparison · 2026

AOD-9604 vs CagriSema

AOD-9604 vs CagriSema — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

AOD-9604
Metabolic & Mitochondrial

AOD-9604 (Anti-Obesity Drug 9604) is a synthetic fragment of human growth hormone (hGH), specifically the C-terminal region spanning amino acids 176-191 with an additional tyrosine at position 177. It was designed to isolate the fat-metabolizing properties of hGH without the IGF-...

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CagriSema
Metabolic & Mitochondrial

9%) and representing one of the strongest obesity pharmacotherapy results in clinical history. The combination works through complementary mechanisms: GLP-1 suppresses appetite centrally while amylin slows gastric emptying and promotes satiety signaling....

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Key Parameters
Parameter AOD-9604 CagriSema
Category Metabolic & Mitochondrial Metabolic & Mitochondrial
Research Phase IIb (Discontinued) Phase III
Half-Life ~30 minutes -
Typical Dose 300 µg Cagrilintide 2.4 mg + Semaglutide 2.4 mg
Frequency Once daily (fasted) Once weekly
Route Subcutaneous / Oral Subcutaneous (weekly)
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between AOD-9604 and CagriSema?
AOD-9604: AOD-9604 (Anti-Obesity Drug 9604) is a synthetic fragment of human growth hormone (hGH), specifically the C-terminal region spanning amino acids 176-191 with an additional tyrosine at position 177. It... CagriSema: 9%) and representing one of the strongest obesity pharmacotherapy results in clinical history. The combination works through complementary mechanisms: GLP-1 suppresses appetite centrally while amylin ...
Which has a longer half-life, AOD-9604 or CagriSema?
AOD-9604 half-life: ~30 minutes. CagriSema half-life: unknown.
Can you stack AOD-9604 and CagriSema?
AOD-9604 and CagriSema are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.