Side-by-Side Comparison · 2026

AOD-9604 vs Mazdutide

AOD-9604 vs Mazdutide — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

AOD-9604
Metabolic & Mitochondrial

AOD-9604 (Anti-Obesity Drug 9604) is a synthetic fragment of human growth hormone (hGH), specifically the C-terminal region spanning amino acids 176-191 with an additional tyrosine at position 177. It was designed to isolate the fat-metabolizing properties of hGH without the IGF-...

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Mazdutide
Metabolic & Mitochondrial

Mazdutide (IBI362) is a once-weekly GLP-1/glucagon receptor dual agonist developed by Innovent Biologics. By activating both receptors simultaneously, it combines the appetite suppression and insulin-sensitizing effects of GLP-1 agonism with the fat-oxidizing and energy-expenditu...

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Key Parameters
Parameter AOD-9604 Mazdutide
Category Metabolic & Mitochondrial Metabolic & Mitochondrial
Research Phase IIb (Discontinued) Phase III (China)
Half-Life ~30 minutes ~7 days
Typical Dose 300 µg 3–9 mg
Frequency Once daily (fasted) Once weekly
Route Subcutaneous / Oral Subcutaneous (weekly)
FDA Status Not Approved Not Approved

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Frequently Asked Questions
What is the difference between AOD-9604 and Mazdutide?
AOD-9604: AOD-9604 (Anti-Obesity Drug 9604) is a synthetic fragment of human growth hormone (hGH), specifically the C-terminal region spanning amino acids 176-191 with an additional tyrosine at position 177. It... Mazdutide: Mazdutide (IBI362) is a once-weekly GLP-1/glucagon receptor dual agonist developed by Innovent Biologics. By activating both receptors simultaneously, it combines the appetite suppression and insulin-...
Which has a longer half-life, AOD-9604 or Mazdutide?
AOD-9604 half-life: ~30 minutes. Mazdutide half-life: ~7 days.
Can you stack AOD-9604 and Mazdutide?
AOD-9604 and Mazdutide are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.