Side-by-Side Comparison · 2026

AOD-9604 vs NAD+

AOD-9604 vs NAD+ — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

AOD-9604
Metabolic & Mitochondrial

AOD-9604 (Anti-Obesity Drug 9604) is a synthetic fragment of human growth hormone (hGH), specifically the C-terminal region spanning amino acids 176-191 with an additional tyrosine at position 177. It was designed to isolate the fat-metabolizing properties of hGH without the IGF-...

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NAD+
Metabolic & Mitochondrial

NAD+ is a coenzyme present in every cell, essential for mitochondrial ATP production via electron transport, DNA repair via PARP enzymes, and sirtuin deacetylase activation. Levels decline approximately 50% between age 20 and 60. Restored through IV therapy or oral precursors NMN...

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Key Parameters
Parameter AOD-9604 NAD+
Category Metabolic & Mitochondrial Metabolic & Mitochondrial
Research Phase IIb (Discontinued) Widely Studied
Half-Life ~30 minutes Very short (direct IV); precursors have hours-long kinetics
Typical Dose 300 µg 250–1,000 mg (IV)
Frequency Once daily (fasted) 2–3x weekly (IV therapy); daily (oral precursors)
Route Subcutaneous / Oral IV / IM / Oral (as precursors NMN, NR)
FDA Status Not Approved Not Approved (drug use)

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Frequently Asked Questions
What is the difference between AOD-9604 and NAD+?
AOD-9604: AOD-9604 (Anti-Obesity Drug 9604) is a synthetic fragment of human growth hormone (hGH), specifically the C-terminal region spanning amino acids 176-191 with an additional tyrosine at position 177. It... NAD+: NAD+ is a coenzyme present in every cell, essential for mitochondrial ATP production via electron transport, DNA repair via PARP enzymes, and sirtuin deacetylase activation. Levels decline approximate...
Which has a longer half-life, AOD-9604 or NAD+?
AOD-9604 half-life: ~30 minutes. NAD+ half-life: Very short (direct IV); precursors have hours-long kinetics.
Can you stack AOD-9604 and NAD+?
AOD-9604 and NAD+ are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.