Side-by-Side Comparison · 2026

Apamin vs Melittin

Apamin vs Melittin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Apamin
Venom Peptide

Apamin is an 18-amino acid peptide neurotoxin from bee venom (Apis mellifera), notable as one of the smallest naturally occurring neurotoxic peptides. This pharmacological selectivity has made apamin an invaluable tool for dissecting SK channel contributions to neuronal excitabil...

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Melittin
Venom Peptide

Melittin is the primary cytolytic component of bee venom (Apis mellifera), comprising ~50% of dry venom weight. It is a 26-amino acid amphipathic, cationic peptide that forms an alpha-helix in membrane environments and disrupts lipid bilayers via a detergent-like mechanism....

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Key Parameters
Parameter Apamin Melittin
Category Venom Peptide Venom Peptide
Research Preclinical/Research Tool Preclinical
Half-Life ~30 min (plasma) < 30 min (plasma)
Typical Dose Research only (ug/kg range) Research only
Frequency N/A N/A
Route IV, SC (research) IV, topical (research)
FDA Status No approval No approval

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Frequently Asked Questions
What is the difference between Apamin and Melittin?
Apamin: Apamin is an 18-amino acid peptide neurotoxin from bee venom (Apis mellifera), notable as one of the smallest naturally occurring neurotoxic peptides. This pharmacological selectivity has made apamin ... Melittin: Melittin is the primary cytolytic component of bee venom (Apis mellifera), comprising ~50% of dry venom weight. It is a 26-amino acid amphipathic, cationic peptide that forms an alpha-helix in membran...
Which has a longer half-life, Apamin or Melittin?
Apamin half-life: ~30 min (plasma). Melittin half-life: < 30 min (plasma).
Can you stack Apamin and Melittin?
Apamin and Melittin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.