Side-by-Side Comparison · 2026

Apelin-13 vs Elabela

Apelin-13 vs Elabela — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Apelin-13
Cardiovascular Peptide

Apelin-13 is the most biologically active isoform of the apelin peptide family, endogenous ligands for the APJ receptor (also called APLNR). Apelin peptides are produced throughout the body, with the heart, lung, brain, and adipose tissue expressing particularly high levels....

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Elabela
Cardiovascular Peptide

Elabela (also called Apela or Toddler) is the second endogenous peptide ligand for the APJ receptor, discovered in 2013 independently through two approaches: as an essential zebrafish cardiac development factor (Toddler) and as a novel human APJ ligand (Elabela). Unlike apelin pe...

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Key Parameters
Parameter Apelin-13 Elabela
Category Cardiovascular Peptide Cardiovascular Peptide
Research Clinical Research
Half-Life < 5 min (plasma) Short (minutes, estimated)
Typical Dose 50-300 nmol/kg 5-500 nmol/kg (animal)
Frequency Variable Variable
Route Intravenous (research), Subcutaneous Subcutaneous, Intravenous
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Apelin-13 and Elabela?
Apelin-13: Apelin-13 is the most biologically active isoform of the apelin peptide family, endogenous ligands for the APJ receptor (also called APLNR). Apelin peptides are produced throughout the body, with the ... Elabela: Elabela (also called Apela or Toddler) is the second endogenous peptide ligand for the APJ receptor, discovered in 2013 independently through two approaches: as an essential zebrafish cardiac developm...
Which has a longer half-life, Apelin-13 or Elabela?
Apelin-13 half-life: < 5 min (plasma). Elabela half-life: Short (minutes, estimated).
Can you stack Apelin-13 and Elabela?
Apelin-13 and Elabela are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.