Side-by-Side Comparison · 2026

Apelin-13 vs Relaxin-2

Apelin-13 vs Relaxin-2 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Apelin-13
Cardiovascular Peptide

Apelin-13 is the most biologically active isoform of the apelin peptide family, endogenous ligands for the APJ receptor (also called APLNR). Apelin peptides are produced throughout the body, with the heart, lung, brain, and adipose tissue expressing particularly high levels....

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Relaxin-2
Cardiovascular Peptide

Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tissue remodeling. Beyond reproduction, relaxin-2 is a systemic anti-fibrotic and v...

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Key Parameters
Parameter Apelin-13 Relaxin-2
Category Cardiovascular Peptide Cardiovascular Peptide
Research Clinical Clinical
Half-Life < 5 min (plasma) 10-15 min (plasma)
Typical Dose 50-300 nmol/kg 30-300 mcg/kg/day (IV)
Frequency Variable Continuous 48-hour infusion (trials)
Route Intravenous (research), Subcutaneous Intravenous (infusion)
FDA Status Not approved Not approved (Phase III completed)

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Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

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Frequently Asked Questions
What is the difference between Apelin-13 and Relaxin-2?
Apelin-13: Apelin-13 is the most biologically active isoform of the apelin peptide family, endogenous ligands for the APJ receptor (also called APLNR). Apelin peptides are produced throughout the body, with the ... Relaxin-2: Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tis...
Which has a longer half-life, Apelin-13 or Relaxin-2?
Apelin-13 half-life: < 5 min (plasma). Relaxin-2 half-life: 10-15 min (plasma).
Can you stack Apelin-13 and Relaxin-2?
Apelin-13 and Relaxin-2 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.