Side-by-Side Comparison · 2026

Apelin-17 vs Intermedin

Apelin-17 vs Intermedin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Apelin-17
Cardiovascular Peptide

Apelin-17 is a 17-amino acid C-terminal fragment of the prepro-apelin precursor that binds and activates the APJ receptor (now APLNR) with the highest potency of all naturally occurring apelin isoforms. While apelin-13 is the best-characterized isoform, apelin-17 shows greater re...

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Intermedin
Cardiovascular Peptide

Intermedin (also called Adrenomedullin 2, AM2) is a 47-53 amino acid peptide belonging to the calcitonin gene-related peptide (CGRP)/adrenomedullin superfamily. Discovered in 2004, intermedin is widely expressed in the heart, lung, kidney, gut, and brain....

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Key Parameters
Parameter Apelin-17 Intermedin
Category Cardiovascular Peptide Cardiovascular Peptide
Research Preclinical / Phase I Preclinical Research
Half-Life ~3-5 minutes IV (longer than apelin-13) ~15-30 minutes
Typical Dose 30-100 nmol/kg/min (IV infusion, clinical) 1-100 pmol/kg/min infusion (animal)
Frequency Acute infusion protocols Acute infusion
Route IV infusion (clinical studies); SC under investigation IV (research); SC in some studies
FDA Status Investigational (Phase I/II) Research compound

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Frequently Asked Questions
What is the difference between Apelin-17 and Intermedin?
Apelin-17: Apelin-17 is a 17-amino acid C-terminal fragment of the prepro-apelin precursor that binds and activates the APJ receptor (now APLNR) with the highest potency of all naturally occurring apelin isoform... Intermedin: Intermedin (also called Adrenomedullin 2, AM2) is a 47-53 amino acid peptide belonging to the calcitonin gene-related peptide (CGRP)/adrenomedullin superfamily. Discovered in 2004, intermedin is widel...
Which has a longer half-life, Apelin-17 or Intermedin?
Apelin-17 half-life: ~3-5 minutes IV (longer than apelin-13). Intermedin half-life: ~15-30 minutes.
Can you stack Apelin-17 and Intermedin?
Apelin-17 and Intermedin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.