Side-by-Side Comparison · 2026

Apelin-17 vs Relaxin-2

Apelin-17 vs Relaxin-2 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Apelin-17
Cardiovascular Peptide

Apelin-17 is a 17-amino acid C-terminal fragment of the prepro-apelin precursor that binds and activates the APJ receptor (now APLNR) with the highest potency of all naturally occurring apelin isoforms. While apelin-13 is the best-characterized isoform, apelin-17 shows greater re...

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Relaxin-2
Cardiovascular Peptide

Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tissue remodeling. Beyond reproduction, relaxin-2 is a systemic anti-fibrotic and v...

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Key Parameters
Parameter Apelin-17 Relaxin-2
Category Cardiovascular Peptide Cardiovascular Peptide
Research Preclinical / Phase I Clinical
Half-Life ~3-5 minutes IV (longer than apelin-13) 10-15 min (plasma)
Typical Dose 30-100 nmol/kg/min (IV infusion, clinical) 30-300 mcg/kg/day (IV)
Frequency Acute infusion protocols Continuous 48-hour infusion (trials)
Route IV infusion (clinical studies); SC under investigation Intravenous (infusion)
FDA Status Investigational (Phase I/II) Not approved (Phase III completed)

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Frequently Asked Questions
What is the difference between Apelin-17 and Relaxin-2?
Apelin-17: Apelin-17 is a 17-amino acid C-terminal fragment of the prepro-apelin precursor that binds and activates the APJ receptor (now APLNR) with the highest potency of all naturally occurring apelin isoform... Relaxin-2: Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tis...
Which has a longer half-life, Apelin-17 or Relaxin-2?
Apelin-17 half-life: ~3-5 minutes IV (longer than apelin-13). Relaxin-2 half-life: 10-15 min (plasma).
Can you stack Apelin-17 and Relaxin-2?
Apelin-17 and Relaxin-2 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.