Side-by-Side Comparison · 2026

Apelin-17 vs Vasostatin

Apelin-17 vs Vasostatin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Apelin-17
Cardiovascular Peptide

Apelin-17 is a 17-amino acid C-terminal fragment of the prepro-apelin precursor that binds and activates the APJ receptor (now APLNR) with the highest potency of all naturally occurring apelin isoforms. While apelin-13 is the best-characterized isoform, apelin-17 shows greater re...

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Vasostatin
Cardiovascular Peptide

Vasostatin refers to the N-terminal fragments of chromogranin A (CgA), particularly CgA1-76 (Vasostatin-1) and CgA1-113 (Vasostatin-2), generated by proteolytic processing of the chromogranin A precursor. While catestatin (CgA352-372) is the C-terminal CgA fragment with anti-cate...

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Key Parameters
Parameter Apelin-17 Vasostatin
Category Cardiovascular Peptide Cardiovascular Peptide
Research Preclinical / Phase I Preclinical Research
Half-Life ~3-5 minutes IV (longer than apelin-13) ~20-30 minutes (estimated)
Typical Dose 30-100 nmol/kg/min (IV infusion, clinical) 0.1-10 nmol/kg IV (animal)
Frequency Acute infusion protocols Acute dosing
Route IV infusion (clinical studies); SC under investigation IV (research)
FDA Status Investigational (Phase I/II) Research compound

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Frequently Asked Questions
What is the difference between Apelin-17 and Vasostatin?
Apelin-17: Apelin-17 is a 17-amino acid C-terminal fragment of the prepro-apelin precursor that binds and activates the APJ receptor (now APLNR) with the highest potency of all naturally occurring apelin isoform... Vasostatin: Vasostatin refers to the N-terminal fragments of chromogranin A (CgA), particularly CgA1-76 (Vasostatin-1) and CgA1-113 (Vasostatin-2), generated by proteolytic processing of the chromogranin A precur...
Which has a longer half-life, Apelin-17 or Vasostatin?
Apelin-17 half-life: ~3-5 minutes IV (longer than apelin-13). Vasostatin half-life: ~20-30 minutes (estimated).
Can you stack Apelin-17 and Vasostatin?
Apelin-17 and Vasostatin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.