Side-by-Side Comparison · 2026

Apelin-36 vs Elabela

Apelin-36 vs Elabela — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Apelin-36
Cardiovascular Peptide

Apelin-36 is the full-length 36-amino acid form of the apelin peptide family, encoded by the APLN gene. It activates the APJ (APLNR) receptor, a Gi-coupled GPCR, producing cardiovascular effects including vasodilation, positive inotropy, and cardioprotection. The largest naturall...

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Elabela
Cardiovascular Peptide

Elabela (also called Apela or Toddler) is the second endogenous peptide ligand for the APJ receptor, discovered in 2013 independently through two approaches: as an essential zebrafish cardiac development factor (Toddler) and as a novel human APJ ligand (Elabela). Unlike apelin pe...

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Key Parameters
Parameter Apelin-36 Elabela
Category Cardiovascular Peptide Cardiovascular Peptide
Research Preclinical / Phase 2 Research
Half-Life 2-5 minutes (IV) Short (minutes, estimated)
Typical Dose 1-10 nmol/kg IV (research) 5-500 nmol/kg (animal)
Frequency Variable Variable
Route IV / SC (research) Subcutaneous, Intravenous
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Apelin-36 and Elabela?
Apelin-36: Apelin-36 is the full-length 36-amino acid form of the apelin peptide family, encoded by the APLN gene. It activates the APJ (APLNR) receptor, a Gi-coupled GPCR, producing cardiovascular effects inclu... Elabela: Elabela (also called Apela or Toddler) is the second endogenous peptide ligand for the APJ receptor, discovered in 2013 independently through two approaches: as an essential zebrafish cardiac developm...
Which has a longer half-life, Apelin-36 or Elabela?
Apelin-36 half-life: 2-5 minutes (IV). Elabela half-life: Short (minutes, estimated).
Can you stack Apelin-36 and Elabela?
Apelin-36 and Elabela are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.