Side-by-Side Comparison · 2026

Apelin-36 vs Intermedin

Apelin-36 vs Intermedin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Apelin-36
Cardiovascular Peptide

Apelin-36 is the full-length 36-amino acid form of the apelin peptide family, encoded by the APLN gene. It activates the APJ (APLNR) receptor, a Gi-coupled GPCR, producing cardiovascular effects including vasodilation, positive inotropy, and cardioprotection. The largest naturall...

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Intermedin
Cardiovascular Peptide

Intermedin (also called Adrenomedullin 2, AM2) is a 47-53 amino acid peptide belonging to the calcitonin gene-related peptide (CGRP)/adrenomedullin superfamily. Discovered in 2004, intermedin is widely expressed in the heart, lung, kidney, gut, and brain....

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Key Parameters
Parameter Apelin-36 Intermedin
Category Cardiovascular Peptide Cardiovascular Peptide
Research Preclinical / Phase 2 Preclinical Research
Half-Life 2-5 minutes (IV) ~15-30 minutes
Typical Dose 1-10 nmol/kg IV (research) 1-100 pmol/kg/min infusion (animal)
Frequency Variable Acute infusion
Route IV / SC (research) IV (research); SC in some studies
FDA Status Not approved Research compound

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Frequently Asked Questions
What is the difference between Apelin-36 and Intermedin?
Apelin-36: Apelin-36 is the full-length 36-amino acid form of the apelin peptide family, encoded by the APLN gene. It activates the APJ (APLNR) receptor, a Gi-coupled GPCR, producing cardiovascular effects inclu... Intermedin: Intermedin (also called Adrenomedullin 2, AM2) is a 47-53 amino acid peptide belonging to the calcitonin gene-related peptide (CGRP)/adrenomedullin superfamily. Discovered in 2004, intermedin is widel...
Which has a longer half-life, Apelin-36 or Intermedin?
Apelin-36 half-life: 2-5 minutes (IV). Intermedin half-life: ~15-30 minutes.
Can you stack Apelin-36 and Intermedin?
Apelin-36 and Intermedin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.