Side-by-Side Comparison · 2026

Apelin-36 vs Relaxin-2

Apelin-36 vs Relaxin-2 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Apelin-36
Cardiovascular Peptide

Apelin-36 is the full-length 36-amino acid form of the apelin peptide family, encoded by the APLN gene. It activates the APJ (APLNR) receptor, a Gi-coupled GPCR, producing cardiovascular effects including vasodilation, positive inotropy, and cardioprotection. The largest naturall...

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Relaxin-2
Cardiovascular Peptide

Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tissue remodeling. Beyond reproduction, relaxin-2 is a systemic anti-fibrotic and v...

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Key Parameters
Parameter Apelin-36 Relaxin-2
Category Cardiovascular Peptide Cardiovascular Peptide
Research Preclinical / Phase 2 Clinical
Half-Life 2-5 minutes (IV) 10-15 min (plasma)
Typical Dose 1-10 nmol/kg IV (research) 30-300 mcg/kg/day (IV)
Frequency Variable Continuous 48-hour infusion (trials)
Route IV / SC (research) Intravenous (infusion)
FDA Status Not approved Not approved (Phase III completed)

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Frequently Asked Questions
What is the difference between Apelin-36 and Relaxin-2?
Apelin-36: Apelin-36 is the full-length 36-amino acid form of the apelin peptide family, encoded by the APLN gene. It activates the APJ (APLNR) receptor, a Gi-coupled GPCR, producing cardiovascular effects inclu... Relaxin-2: Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tis...
Which has a longer half-life, Apelin-36 or Relaxin-2?
Apelin-36 half-life: 2-5 minutes (IV). Relaxin-2 half-life: 10-15 min (plasma).
Can you stack Apelin-36 and Relaxin-2?
Apelin-36 and Relaxin-2 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.