Side-by-Side Comparison · 2026

Apelin-36 vs Vasostatin

Apelin-36 vs Vasostatin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Apelin-36
Cardiovascular Peptide

Apelin-36 is the full-length 36-amino acid form of the apelin peptide family, encoded by the APLN gene. It activates the APJ (APLNR) receptor, a Gi-coupled GPCR, producing cardiovascular effects including vasodilation, positive inotropy, and cardioprotection. The largest naturall...

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Vasostatin
Cardiovascular Peptide

Vasostatin refers to the N-terminal fragments of chromogranin A (CgA), particularly CgA1-76 (Vasostatin-1) and CgA1-113 (Vasostatin-2), generated by proteolytic processing of the chromogranin A precursor. While catestatin (CgA352-372) is the C-terminal CgA fragment with anti-cate...

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Key Parameters
Parameter Apelin-36 Vasostatin
Category Cardiovascular Peptide Cardiovascular Peptide
Research Preclinical / Phase 2 Preclinical Research
Half-Life 2-5 minutes (IV) ~20-30 minutes (estimated)
Typical Dose 1-10 nmol/kg IV (research) 0.1-10 nmol/kg IV (animal)
Frequency Variable Acute dosing
Route IV / SC (research) IV (research)
FDA Status Not approved Research compound

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Frequently Asked Questions
What is the difference between Apelin-36 and Vasostatin?
Apelin-36: Apelin-36 is the full-length 36-amino acid form of the apelin peptide family, encoded by the APLN gene. It activates the APJ (APLNR) receptor, a Gi-coupled GPCR, producing cardiovascular effects inclu... Vasostatin: Vasostatin refers to the N-terminal fragments of chromogranin A (CgA), particularly CgA1-76 (Vasostatin-1) and CgA1-113 (Vasostatin-2), generated by proteolytic processing of the chromogranin A precur...
Which has a longer half-life, Apelin-36 or Vasostatin?
Apelin-36 half-life: 2-5 minutes (IV). Vasostatin half-life: ~20-30 minutes (estimated).
Can you stack Apelin-36 and Vasostatin?
Apelin-36 and Vasostatin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.