Side-by-Side Comparison · 2026

Aurein vs Polyphemusin

Aurein vs Polyphemusin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Aurein
Antimicrobial Peptide

Aurein peptides are a large family of short (13-25 residue) antimicrobial and anticancer peptides isolated from the Australian green and golden bell frog Litoria aurea and related species. 2 is the smallest member with activity against Gram-positive bacteria....

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Polyphemusin
Antimicrobial Peptide

Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a disulfide-bridged beta-hairpin with potent antimicrobial activity....

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Key Parameters
Parameter Aurein Polyphemusin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Minutes (proteolytic) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Aurein and Polyphemusin?
Aurein: Aurein peptides are a large family of short (13-25 residue) antimicrobial and anticancer peptides isolated from the Australian green and golden bell frog Litoria aurea and related species. 2 is the sm... Polyphemusin: Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a dis...
Which has a longer half-life, Aurein or Polyphemusin?
Aurein half-life: Minutes (proteolytic). Polyphemusin half-life: Hours (disulfide stabilized).
Can you stack Aurein and Polyphemusin?
Aurein and Polyphemusin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.