Side-by-Side Comparison · 2026

Aurein vs Protegrin

Aurein vs Protegrin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Aurein
Antimicrobial Peptide

Aurein peptides are a large family of short (13-25 residue) antimicrobial and anticancer peptides isolated from the Australian green and golden bell frog Litoria aurea and related species. 2 is the smallest member with activity against Gram-positive bacteria....

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Protegrin
Antimicrobial Peptide

Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative bacteria, including multidrug-resistant organisms....

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Key Parameters
Parameter Aurein Protegrin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Phase III (failed)
Half-Life Minutes (proteolytic) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Topical / Rinse
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Aurein and Protegrin?
Aurein: Aurein peptides are a large family of short (13-25 residue) antimicrobial and anticancer peptides isolated from the Australian green and golden bell frog Litoria aurea and related species. 2 is the sm... Protegrin: Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative ba...
Which has a longer half-life, Aurein or Protegrin?
Aurein half-life: Minutes (proteolytic). Protegrin half-life: Hours (disulfide stabilized).
Can you stack Aurein and Protegrin?
Aurein and Protegrin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.