Side-by-Side Comparison · 2026

Bacitracin vs Protegrin-1

Bacitracin vs Protegrin-1 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Bacitracin
Antimicrobial Peptide

Bacitracin is a polycyclic peptide antibiotic from Bacillus subtilis licheniformis, first isolated in 1945 from wound cultures of a 7-year-old girl named Margaret Tracy (hence "bacitracin"). It is available OTC in Neosporin and similar triple-antibiotic ointments and is one of th...

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Protegrin-1
Antimicrobial Peptide

Protegrin-1 (PG-1) is an 18-residue cationic beta-hairpin antimicrobial peptide isolated from porcine leukocytes. It is stabilized by two intramolecular disulfide bonds that lock its hairpin conformation....

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Key Parameters
Parameter Bacitracin Protegrin-1
Category Antimicrobial Peptide Antimicrobial Peptide
Research FDA Approved (topical) Phase 3 / Clinical
Half-Life Hours (topical) Short
Typical Dose 400-500 units/g ointment 0.1-1 mg/mL (topical)
Frequency 1-3x daily BID-TID
Route Topical Topical / Oral rinse (research)
FDA Status Approved (topical) Phase 3 clinical evaluation (iseganan)

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Frequently Asked Questions
What is the difference between Bacitracin and Protegrin-1?
Bacitracin: Bacitracin is a polycyclic peptide antibiotic from Bacillus subtilis licheniformis, first isolated in 1945 from wound cultures of a 7-year-old girl named Margaret Tracy (hence "bacitracin"). It is ava... Protegrin-1: Protegrin-1 (PG-1) is an 18-residue cationic beta-hairpin antimicrobial peptide isolated from porcine leukocytes. It is stabilized by two intramolecular disulfide bonds that lock its hairpin conformat...
Which has a longer half-life, Bacitracin or Protegrin-1?
Bacitracin half-life: Hours (topical). Protegrin-1 half-life: Short.
Can you stack Bacitracin and Protegrin-1?
Bacitracin and Protegrin-1 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.