Side-by-Side Comparison · 2026

Bactenecin vs PR-39

Bactenecin vs PR-39 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Bactenecin
Antimicrobial Peptide

Bactenecins are a diverse family of antimicrobial peptides from bovine neutrophil granules. The family includes both the small cyclic dodecapeptide Bac1 (with one disulfide bond) and the larger linear proline-rich Bac5 and Bac7....

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PR-39
Antimicrobial Peptide

PR-39 is a 39-residue proline- and arginine-rich antimicrobial peptide from porcine neutrophil granules. Unlike classical membrane-disrupting AMPs, PR-39 kills bacteria intracellularly by inhibiting DNA and protein synthesis....

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Key Parameters
Parameter Bactenecin PR-39
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Minutes (proteolytic) Minutes (proteolytic)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Bactenecin and PR-39?
Bactenecin: Bactenecins are a diverse family of antimicrobial peptides from bovine neutrophil granules. The family includes both the small cyclic dodecapeptide Bac1 (with one disulfide bond) and the larger linear... PR-39: PR-39 is a 39-residue proline- and arginine-rich antimicrobial peptide from porcine neutrophil granules. Unlike classical membrane-disrupting AMPs, PR-39 kills bacteria intracellularly by inhibiting D...
Which has a longer half-life, Bactenecin or PR-39?
Bactenecin half-life: Minutes (proteolytic). PR-39 half-life: Minutes (proteolytic).
Can you stack Bactenecin and PR-39?
Bactenecin and PR-39 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.