Side-by-Side Comparison · 2026

Big Endothelin-1 vs Sarafotoxin

Big Endothelin-1 vs Sarafotoxin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Big Endothelin-1
Vasoactive Peptide

Big endothelin-1 (big ET-1) is a 38-amino acid peptide that is the direct precursor to the potent vasoconstrictor endothelin-1 (ET-1). It is produced by vascular endothelial cells from preproendothelin-1 and cleaved to the active 21-amino acid ET-1 by endothelin-converting enzyme...

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Sarafotoxin
Vasoactive Peptide

Sarafotoxins are a family of 21-amino acid peptides isolated from the venom of the Israeli burrowing asp (Atractaspis engaddensis). They are structural and functional homologs of endothelin-1, sharing ~60% sequence identity and acting on the same ETA/ETB receptor subtypes....

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Key Parameters
Parameter Big Endothelin-1 Sarafotoxin
Category Vasoactive Peptide Vasoactive Peptide
Research Preclinical/Biomarker Pharmacological Tool
Half-Life Longer than ET-1 (~plasma half-life 3-5 min ET-1) Minutes (plasma)
Typical Dose Research only Research only (nmol/kg)
Frequency N/A N/A
Route Endogenous; IV (research) IV (research only)
FDA Status No approval No approval

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Frequently Asked Questions
What is the difference between Big Endothelin-1 and Sarafotoxin?
Big Endothelin-1: Big endothelin-1 (big ET-1) is a 38-amino acid peptide that is the direct precursor to the potent vasoconstrictor endothelin-1 (ET-1). It is produced by vascular endothelial cells from preproendotheli... Sarafotoxin: Sarafotoxins are a family of 21-amino acid peptides isolated from the venom of the Israeli burrowing asp (Atractaspis engaddensis). They are structural and functional homologs of endothelin-1, sharing...
Which has a longer half-life, Big Endothelin-1 or Sarafotoxin?
Big Endothelin-1 half-life: Longer than ET-1 (~plasma half-life 3-5 min ET-1). Sarafotoxin half-life: Minutes (plasma).
Can you stack Big Endothelin-1 and Sarafotoxin?
Big Endothelin-1 and Sarafotoxin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.