Side-by-Side Comparison · 2026

Brevinin vs Cathelicidin (LL-37)

Brevinin vs Cathelicidin (LL-37) — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Brevinin
Antimicrobial Peptide

Brevinin peptides are a family of antimicrobial peptides isolated from the skin secretions of Rana esculenta (European edible frog) and related Rana species. They are characterized by a C-terminal disulfide-bridged cyclic heptapeptide (Rana box) that confers structural stability ...

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Cathelicidin (LL-37)
Antimicrobial Peptide

LL-37 is the sole human cathelicidin antimicrobial peptide, derived by proteolytic cleavage of the 18 kDa precursor hCAP18 (encoded by the CAMP gene). It is produced by neutrophils, epithelial cells of the skin, gut, and airways, and mast cells....

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Key Parameters
Parameter Brevinin Cathelicidin (LL-37)
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Clinical Research
Half-Life Minutes (proteolytic) < 10 min (plasma)
Typical Dose N/A Research: 1-100 ug/mL (topical)
Frequency N/A Varies by application
Route Research only Endogenous; topical/inhalation (research)
FDA Status Not approved No approval (clinical trials ongoing)

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Frequently Asked Questions
What is the difference between Brevinin and Cathelicidin (LL-37)?
Brevinin: Brevinin peptides are a family of antimicrobial peptides isolated from the skin secretions of Rana esculenta (European edible frog) and related Rana species. They are characterized by a C-terminal dis... Cathelicidin (LL-37): LL-37 is the sole human cathelicidin antimicrobial peptide, derived by proteolytic cleavage of the 18 kDa precursor hCAP18 (encoded by the CAMP gene). It is produced by neutrophils, epithelial cells o...
Which has a longer half-life, Brevinin or Cathelicidin (LL-37)?
Brevinin half-life: Minutes (proteolytic). Cathelicidin (LL-37) half-life: < 10 min (plasma).
Can you stack Brevinin and Cathelicidin (LL-37)?
Brevinin and Cathelicidin (LL-37) are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.