Side-by-Side Comparison · 2026

Brevinin vs PR-39

Brevinin vs PR-39 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Brevinin
Antimicrobial Peptide

Brevinin peptides are a family of antimicrobial peptides isolated from the skin secretions of Rana esculenta (European edible frog) and related Rana species. They are characterized by a C-terminal disulfide-bridged cyclic heptapeptide (Rana box) that confers structural stability ...

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PR-39
Antimicrobial Peptide

PR-39 is a 39-residue proline- and arginine-rich antimicrobial peptide from porcine neutrophil granules. Unlike classical membrane-disrupting AMPs, PR-39 kills bacteria intracellularly by inhibiting DNA and protein synthesis....

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Key Parameters
Parameter Brevinin PR-39
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Minutes (proteolytic) Minutes (proteolytic)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Brevinin and PR-39?
Brevinin: Brevinin peptides are a family of antimicrobial peptides isolated from the skin secretions of Rana esculenta (European edible frog) and related Rana species. They are characterized by a C-terminal dis... PR-39: PR-39 is a 39-residue proline- and arginine-rich antimicrobial peptide from porcine neutrophil granules. Unlike classical membrane-disrupting AMPs, PR-39 kills bacteria intracellularly by inhibiting D...
Which has a longer half-life, Brevinin or PR-39?
Brevinin half-life: Minutes (proteolytic). PR-39 half-life: Minutes (proteolytic).
Can you stack Brevinin and PR-39?
Brevinin and PR-39 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.