Side-by-Side Comparison · 2026

Brevinin vs Protegrin

Brevinin vs Protegrin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Brevinin
Antimicrobial Peptide

Brevinin peptides are a family of antimicrobial peptides isolated from the skin secretions of Rana esculenta (European edible frog) and related Rana species. They are characterized by a C-terminal disulfide-bridged cyclic heptapeptide (Rana box) that confers structural stability ...

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Protegrin
Antimicrobial Peptide

Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative bacteria, including multidrug-resistant organisms....

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Key Parameters
Parameter Brevinin Protegrin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Phase III (failed)
Half-Life Minutes (proteolytic) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Topical / Rinse
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Brevinin and Protegrin?
Brevinin: Brevinin peptides are a family of antimicrobial peptides isolated from the skin secretions of Rana esculenta (European edible frog) and related Rana species. They are characterized by a C-terminal dis... Protegrin: Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative ba...
Which has a longer half-life, Brevinin or Protegrin?
Brevinin half-life: Minutes (proteolytic). Protegrin half-life: Hours (disulfide stabilized).
Can you stack Brevinin and Protegrin?
Brevinin and Protegrin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.