Side-by-Side Comparison · 2026

Buforin II vs Cathelicidin (LL-37)

Buforin II vs Cathelicidin (LL-37) — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Buforin II
Antimicrobial Peptide

Buforin II is a 21-residue antimicrobial peptide derived from histone H2A in the stomach of the Asian toad Bufo gargarizans. Unlike most AMPs that kill bacteria by membrane disruption, Buforin II translocates across bacterial membranes without causing lysis and kills by binding n...

Calculate Buforin II dose →
Cathelicidin (LL-37)
Antimicrobial Peptide

LL-37 is the sole human cathelicidin antimicrobial peptide, derived by proteolytic cleavage of the 18 kDa precursor hCAP18 (encoded by the CAMP gene). It is produced by neutrophils, epithelial cells of the skin, gut, and airways, and mast cells....

Calculate Cathelicidin (LL-37) dose →
Key Parameters
Parameter Buforin II Cathelicidin (LL-37)
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Clinical Research
Half-Life Minutes (proteolytic) < 10 min (plasma)
Typical Dose N/A Research: 1-100 ug/mL (topical)
Frequency N/A Varies by application
Route Research only Endogenous; topical/inhalation (research)
FDA Status Not approved No approval (clinical trials ongoing)

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate Buforin II Calculate Cathelicidin (LL-37)
Frequently Asked Questions
What is the difference between Buforin II and Cathelicidin (LL-37)?
Buforin II: Buforin II is a 21-residue antimicrobial peptide derived from histone H2A in the stomach of the Asian toad Bufo gargarizans. Unlike most AMPs that kill bacteria by membrane disruption, Buforin II tran... Cathelicidin (LL-37): LL-37 is the sole human cathelicidin antimicrobial peptide, derived by proteolytic cleavage of the 18 kDa precursor hCAP18 (encoded by the CAMP gene). It is produced by neutrophils, epithelial cells o...
Which has a longer half-life, Buforin II or Cathelicidin (LL-37)?
Buforin II half-life: Minutes (proteolytic). Cathelicidin (LL-37) half-life: < 10 min (plasma).
Can you stack Buforin II and Cathelicidin (LL-37)?
Buforin II and Cathelicidin (LL-37) are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.