Side-by-Side Comparison · 2026

Buforin II vs Protegrin

Buforin II vs Protegrin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Buforin II
Antimicrobial Peptide

Buforin II is a 21-residue antimicrobial peptide derived from histone H2A in the stomach of the Asian toad Bufo gargarizans. Unlike most AMPs that kill bacteria by membrane disruption, Buforin II translocates across bacterial membranes without causing lysis and kills by binding n...

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Protegrin
Antimicrobial Peptide

Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative bacteria, including multidrug-resistant organisms....

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Key Parameters
Parameter Buforin II Protegrin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Phase III (failed)
Half-Life Minutes (proteolytic) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Topical / Rinse
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Buforin II and Protegrin?
Buforin II: Buforin II is a 21-residue antimicrobial peptide derived from histone H2A in the stomach of the Asian toad Bufo gargarizans. Unlike most AMPs that kill bacteria by membrane disruption, Buforin II tran... Protegrin: Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative ba...
Which has a longer half-life, Buforin II or Protegrin?
Buforin II half-life: Minutes (proteolytic). Protegrin half-life: Hours (disulfide stabilized).
Can you stack Buforin II and Protegrin?
Buforin II and Protegrin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.