Side-by-Side Comparison · 2026

Caerin vs Polyphemusin

Caerin vs Polyphemusin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Caerin
Antimicrobial Peptide

Caerins are a family of antimicrobial peptides from the Australian Blue Mountains tree frog Litoria caerulea and related species. They adopt a unique helix-kink-helix conformation with a proline-induced kink in the center of the molecule....

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Polyphemusin
Antimicrobial Peptide

Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a disulfide-bridged beta-hairpin with potent antimicrobial activity....

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Key Parameters
Parameter Caerin Polyphemusin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Minutes (proteolytic) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Caerin and Polyphemusin?
Caerin: Caerins are a family of antimicrobial peptides from the Australian Blue Mountains tree frog Litoria caerulea and related species. They adopt a unique helix-kink-helix conformation with a proline-induc... Polyphemusin: Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a dis...
Which has a longer half-life, Caerin or Polyphemusin?
Caerin half-life: Minutes (proteolytic). Polyphemusin half-life: Hours (disulfide stabilized).
Can you stack Caerin and Polyphemusin?
Caerin and Polyphemusin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.