Side-by-Side Comparison · 2026

Caerin vs PR-39

Caerin vs PR-39 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Caerin
Antimicrobial Peptide

Caerins are a family of antimicrobial peptides from the Australian Blue Mountains tree frog Litoria caerulea and related species. They adopt a unique helix-kink-helix conformation with a proline-induced kink in the center of the molecule....

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PR-39
Antimicrobial Peptide

PR-39 is a 39-residue proline- and arginine-rich antimicrobial peptide from porcine neutrophil granules. Unlike classical membrane-disrupting AMPs, PR-39 kills bacteria intracellularly by inhibiting DNA and protein synthesis....

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Key Parameters
Parameter Caerin PR-39
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Minutes (proteolytic) Minutes (proteolytic)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Caerin and PR-39?
Caerin: Caerins are a family of antimicrobial peptides from the Australian Blue Mountains tree frog Litoria caerulea and related species. They adopt a unique helix-kink-helix conformation with a proline-induc... PR-39: PR-39 is a 39-residue proline- and arginine-rich antimicrobial peptide from porcine neutrophil granules. Unlike classical membrane-disrupting AMPs, PR-39 kills bacteria intracellularly by inhibiting D...
Which has a longer half-life, Caerin or PR-39?
Caerin half-life: Minutes (proteolytic). PR-39 half-life: Minutes (proteolytic).
Can you stack Caerin and PR-39?
Caerin and PR-39 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.