Side-by-Side Comparison · 2026

Caerin vs Protegrin

Caerin vs Protegrin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Caerin
Antimicrobial Peptide

Caerins are a family of antimicrobial peptides from the Australian Blue Mountains tree frog Litoria caerulea and related species. They adopt a unique helix-kink-helix conformation with a proline-induced kink in the center of the molecule....

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Protegrin
Antimicrobial Peptide

Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative bacteria, including multidrug-resistant organisms....

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Key Parameters
Parameter Caerin Protegrin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Phase III (failed)
Half-Life Minutes (proteolytic) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Topical / Rinse
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Caerin and Protegrin?
Caerin: Caerins are a family of antimicrobial peptides from the Australian Blue Mountains tree frog Litoria caerulea and related species. They adopt a unique helix-kink-helix conformation with a proline-induc... Protegrin: Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative ba...
Which has a longer half-life, Caerin or Protegrin?
Caerin half-life: Minutes (proteolytic). Protegrin half-life: Hours (disulfide stabilized).
Can you stack Caerin and Protegrin?
Caerin and Protegrin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.