Side-by-Side Comparison · 2026

CGRP vs Relaxin-3

CGRP vs Relaxin-3 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

CGRP
Neuropeptide

Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide produced by alternative splicing of the calcitonin gene in neurons. It is the most abundant neuropeptide in the sensory nervous system, expressed in trigeminal ganglion neurons and released from perivascular n...

Calculate CGRP dose →
Relaxin-3
Neuropeptide

Relaxin-3 (also called INSL7) is the most ancient member of the insulin/relaxin superfamily and is expressed predominantly in the nucleus incertus (NI) of the brainstem, a structure implicated in stress, arousal, and hippocampal theta rhythm generation. Unlike relaxin-1 and relax...

Calculate Relaxin-3 dose →
Key Parameters
Parameter CGRP Relaxin-3
Category Neuropeptide Neuropeptide
Research FDA Approved (Anti-CGRP antibodies) Preclinical Research
Half-Life ~7-10 min (plasma; native) ~30-60 minutes (estimated)
Typical Dose Anti-CGRP mAbs: 70-240 mg SC monthly or quarterly 100-500 pmol ICV; 1-3 nmol/kg SC
Frequency Monthly or quarterly (approved antibodies) Single or twice daily (preclinical)
Route Endogenous; IV/SC (research) ICV, SC (preclinical)
FDA Status Anti-CGRP antibodies approved (erenumab, fremanezumab, galcanezumab, eptinezumab) Research compound

Calculate doses for both

Use ASCEND's free reconstitution calculator to get exact syringe draw amounts for your vial.

Calculate CGRP Calculate Relaxin-3
Frequently Asked Questions
What is the difference between CGRP and Relaxin-3?
CGRP: Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide produced by alternative splicing of the calcitonin gene in neurons. It is the most abundant neuropeptide in the sensory nervous s... Relaxin-3: Relaxin-3 (also called INSL7) is the most ancient member of the insulin/relaxin superfamily and is expressed predominantly in the nucleus incertus (NI) of the brainstem, a structure implicated in stre...
Which has a longer half-life, CGRP or Relaxin-3?
CGRP half-life: ~7-10 min (plasma; native). Relaxin-3 half-life: ~30-60 minutes (estimated).
Can you stack CGRP and Relaxin-3?
CGRP and Relaxin-3 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.