Side-by-Side Comparison · 2026

CART Peptide vs Cortistatin-14

CART Peptide vs Cortistatin-14 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

CART Peptide
Neuropeptide

CART (Cocaine- and Amphetamine-Regulated Transcript) peptide is a neuropeptide encoded by the CARTPT gene, named because its mRNA is dramatically upregulated in the striatum by cocaine and amphetamine administration. CART peptide is produced in the arcuate nucleus, nucleus accumb...

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Cortistatin-14
Neuropeptide

Cortistatin-14 (CST-14) is an endogenous cyclic neuropeptide structurally related to somatostatin, sharing 11 of 14 amino acids with the somatostatin ring structure. Despite this similarity, cortistatin has distinct receptor binding and biological actions....

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Key Parameters
Parameter CART Peptide Cortistatin-14
Category Neuropeptide Neuropeptide
Research Research Research
Half-Life Unknown Short (minutes)
Typical Dose 0.1-10 nmol (ICV, animal) 250-500 mcg (animal)
Frequency Variable Variable
Route Intracerebroventricular (animal research) Subcutaneous, Intraperitoneal
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between CART Peptide and Cortistatin-14?
CART Peptide: CART (Cocaine- and Amphetamine-Regulated Transcript) peptide is a neuropeptide encoded by the CARTPT gene, named because its mRNA is dramatically upregulated in the striatum by cocaine and amphetamine... Cortistatin-14: Cortistatin-14 (CST-14) is an endogenous cyclic neuropeptide structurally related to somatostatin, sharing 11 of 14 amino acids with the somatostatin ring structure. Despite this similarity, cortistat...
Which has a longer half-life, CART Peptide or Cortistatin-14?
CART Peptide half-life: Unknown. Cortistatin-14 half-life: Short (minutes).
Can you stack CART Peptide and Cortistatin-14?
CART Peptide and Cortistatin-14 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.