Side-by-Side Comparison · 2026

Catestatin vs Relaxin-2

Catestatin vs Relaxin-2 — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Catestatin
Cardiovascular Peptide

Catestatin is a 21-amino acid peptide derived from the chromogranin A (CgA) protein, specifically cleaved from the region spanning residues 352-372. It was identified as an endogenous inhibitor of catecholamine secretion, acting as a non-competitive antagonist at nicotinic acetyl...

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Relaxin-2
Cardiovascular Peptide

Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tissue remodeling. Beyond reproduction, relaxin-2 is a systemic anti-fibrotic and v...

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Key Parameters
Parameter Catestatin Relaxin-2
Category Cardiovascular Peptide Cardiovascular Peptide
Research Preclinical / Early Human Clinical
Half-Life ~15-30 minutes (IV) 10-15 min (plasma)
Typical Dose 0.3-3 nmol/kg (animal studies) 30-300 mcg/kg/day (IV)
Frequency Acute dosing in research Continuous 48-hour infusion (trials)
Route IV (research); intranasal under study Intravenous (infusion)
FDA Status Research compound Not approved (Phase III completed)

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Frequently Asked Questions
What is the difference between Catestatin and Relaxin-2?
Catestatin: Catestatin is a 21-amino acid peptide derived from the chromogranin A (CgA) protein, specifically cleaved from the region spanning residues 352-372. It was identified as an endogenous inhibitor of cat... Relaxin-2: Relaxin-2 (H2 Relaxin) is an endogenous peptide hormone of the insulin superfamily, best known for its roles in pregnancy physiology including cervical ripening, uterine quiescence, and connective tis...
Which has a longer half-life, Catestatin or Relaxin-2?
Catestatin half-life: ~15-30 minutes (IV). Relaxin-2 half-life: 10-15 min (plasma).
Can you stack Catestatin and Relaxin-2?
Catestatin and Relaxin-2 are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.