Side-by-Side Comparison · 2026

Cathelicidin (LL-37) vs Dermaseptin

Cathelicidin (LL-37) vs Dermaseptin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Cathelicidin (LL-37)
Antimicrobial Peptide

LL-37 is the sole human cathelicidin antimicrobial peptide, derived by proteolytic cleavage of the 18 kDa precursor hCAP18 (encoded by the CAMP gene). It is produced by neutrophils, epithelial cells of the skin, gut, and airways, and mast cells....

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Dermaseptin
Antimicrobial Peptide

Dermaseptins are a family of 28-34 amino acid antimicrobial peptides first isolated from the skin of South American Phyllomedusa frogs. They are among the most potent broad-spectrum AMPs known, with activity against bacteria, fungi, protozoa, and viruses....

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Key Parameters
Parameter Cathelicidin (LL-37) Dermaseptin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Clinical Research Preclinical
Half-Life < 10 min (plasma) Minutes (proteolytic)
Typical Dose Research: 1-100 ug/mL (topical) N/A (research)
Frequency Varies by application N/A
Route Endogenous; topical/inhalation (research) Topical / Parenteral (research)
FDA Status No approval (clinical trials ongoing) Not approved

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Frequently Asked Questions
What is the difference between Cathelicidin (LL-37) and Dermaseptin?
Cathelicidin (LL-37): LL-37 is the sole human cathelicidin antimicrobial peptide, derived by proteolytic cleavage of the 18 kDa precursor hCAP18 (encoded by the CAMP gene). It is produced by neutrophils, epithelial cells o... Dermaseptin: Dermaseptins are a family of 28-34 amino acid antimicrobial peptides first isolated from the skin of South American Phyllomedusa frogs. They are among the most potent broad-spectrum AMPs known, with a...
Which has a longer half-life, Cathelicidin (LL-37) or Dermaseptin?
Cathelicidin (LL-37) half-life: < 10 min (plasma). Dermaseptin half-life: Minutes (proteolytic).
Can you stack Cathelicidin (LL-37) and Dermaseptin?
Cathelicidin (LL-37) and Dermaseptin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.