Side-by-Side Comparison · 2026

Cathelicidin (LL-37) vs Protegrin

Cathelicidin (LL-37) vs Protegrin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Cathelicidin (LL-37)
Antimicrobial Peptide

LL-37 is the sole human cathelicidin antimicrobial peptide, derived by proteolytic cleavage of the 18 kDa precursor hCAP18 (encoded by the CAMP gene). It is produced by neutrophils, epithelial cells of the skin, gut, and airways, and mast cells....

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Protegrin
Antimicrobial Peptide

Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative bacteria, including multidrug-resistant organisms....

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Key Parameters
Parameter Cathelicidin (LL-37) Protegrin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Clinical Research Phase III (failed)
Half-Life < 10 min (plasma) Hours (disulfide stabilized)
Typical Dose Research: 1-100 ug/mL (topical) N/A
Frequency Varies by application N/A
Route Endogenous; topical/inhalation (research) Topical / Rinse
FDA Status No approval (clinical trials ongoing) Not approved

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Frequently Asked Questions
What is the difference between Cathelicidin (LL-37) and Protegrin?
Cathelicidin (LL-37): LL-37 is the sole human cathelicidin antimicrobial peptide, derived by proteolytic cleavage of the 18 kDa precursor hCAP18 (encoded by the CAMP gene). It is produced by neutrophils, epithelial cells o... Protegrin: Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine leukocytes. Protegrin-1 (PG-1) is one of the most potent AMPs against both Gram-positive and Gram-negative ba...
Which has a longer half-life, Cathelicidin (LL-37) or Protegrin?
Cathelicidin (LL-37) half-life: < 10 min (plasma). Protegrin half-life: Hours (disulfide stabilized).
Can you stack Cathelicidin (LL-37) and Protegrin?
Cathelicidin (LL-37) and Protegrin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.