Side-by-Side Comparison · 2026

Cathelicidin (LL-37) vs Tachyplesin

Cathelicidin (LL-37) vs Tachyplesin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Cathelicidin (LL-37)
Antimicrobial Peptide

LL-37 is the sole human cathelicidin antimicrobial peptide, derived by proteolytic cleavage of the 18 kDa precursor hCAP18 (encoded by the CAMP gene). It is produced by neutrophils, epithelial cells of the skin, gut, and airways, and mast cells....

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Tachyplesin
Antimicrobial Peptide

Tachyplesin I is an 18-residue disulfide-bridged beta-hairpin AMP from the hemocytes of the Japanese horseshoe crab (Tachypleus tridentatus). It exhibits potent antimicrobial, antiviral, and antitumor activity....

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Key Parameters
Parameter Cathelicidin (LL-37) Tachyplesin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Clinical Research Preclinical
Half-Life < 10 min (plasma) Hours (disulfide stabilized)
Typical Dose Research: 1-100 ug/mL (topical) N/A
Frequency Varies by application N/A
Route Endogenous; topical/inhalation (research) Research only
FDA Status No approval (clinical trials ongoing) Not approved

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Frequently Asked Questions
What is the difference between Cathelicidin (LL-37) and Tachyplesin?
Cathelicidin (LL-37): LL-37 is the sole human cathelicidin antimicrobial peptide, derived by proteolytic cleavage of the 18 kDa precursor hCAP18 (encoded by the CAMP gene). It is produced by neutrophils, epithelial cells o... Tachyplesin: Tachyplesin I is an 18-residue disulfide-bridged beta-hairpin AMP from the hemocytes of the Japanese horseshoe crab (Tachypleus tridentatus). It exhibits potent antimicrobial, antiviral, and antitumor...
Which has a longer half-life, Cathelicidin (LL-37) or Tachyplesin?
Cathelicidin (LL-37) half-life: < 10 min (plasma). Tachyplesin half-life: Hours (disulfide stabilized).
Can you stack Cathelicidin (LL-37) and Tachyplesin?
Cathelicidin (LL-37) and Tachyplesin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.