Side-by-Side Comparison · 2026

Cathelicidin (LL-37) vs Temporin

Cathelicidin (LL-37) vs Temporin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Cathelicidin (LL-37)
Antimicrobial Peptide

LL-37 is the sole human cathelicidin antimicrobial peptide, derived by proteolytic cleavage of the 18 kDa precursor hCAP18 (encoded by the CAMP gene). It is produced by neutrophils, epithelial cells of the skin, gut, and airways, and mast cells....

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Temporin
Antimicrobial Peptide

Temporins are a family of short (10-14 amino acid) cationic antimicrobial peptides isolated from the skin secretions of the European common frog (Rana temporaria). First described by Simmaco et al....

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Key Parameters
Parameter Cathelicidin (LL-37) Temporin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Clinical Research Preclinical
Half-Life < 10 min (plasma) Minutes (plasma)
Typical Dose Research: 1-100 ug/mL (topical) Research only
Frequency Varies by application N/A
Route Endogenous; topical/inhalation (research) Topical, in vitro (research)
FDA Status No approval (clinical trials ongoing) No approval

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Frequently Asked Questions
What is the difference between Cathelicidin (LL-37) and Temporin?
Cathelicidin (LL-37): LL-37 is the sole human cathelicidin antimicrobial peptide, derived by proteolytic cleavage of the 18 kDa precursor hCAP18 (encoded by the CAMP gene). It is produced by neutrophils, epithelial cells o... Temporin: Temporins are a family of short (10-14 amino acid) cationic antimicrobial peptides isolated from the skin secretions of the European common frog (Rana temporaria). First described by Simmaco et al....
Which has a longer half-life, Cathelicidin (LL-37) or Temporin?
Cathelicidin (LL-37) half-life: < 10 min (plasma). Temporin half-life: Minutes (plasma).
Can you stack Cathelicidin (LL-37) and Temporin?
Cathelicidin (LL-37) and Temporin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.