Side-by-Side Comparison · 2026

Cecropin vs PGLa

Cecropin vs PGLa — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Cecropin
Antimicrobial Peptide

Cecropins are a family of antimicrobial peptides first discovered in 1980 by Hans Boman in the silkmoth Hyalophora cecropia. Cecropin A was the first AMP characterized from an insect, establishing the paradigm of innate immune peptide-based defense....

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PGLa
Antimicrobial Peptide

PGLa is a 22-residue alpha-helical antimicrobial peptide co-isolated with magainin-2 from the skin of the African clawed frog Xenopus laevis. Individually, PGLa and magainin-2 show modest antimicrobial activity, but when combined at equimolar ratios, they exhibit synergistic kill...

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Key Parameters
Parameter Cecropin PGLa
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Minutes (proteolytic) Minutes (proteolytic)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Cecropin and PGLa?
Cecropin: Cecropins are a family of antimicrobial peptides first discovered in 1980 by Hans Boman in the silkmoth Hyalophora cecropia. Cecropin A was the first AMP characterized from an insect, establishing the... PGLa: PGLa is a 22-residue alpha-helical antimicrobial peptide co-isolated with magainin-2 from the skin of the African clawed frog Xenopus laevis. Individually, PGLa and magainin-2 show modest antimicrobia...
Which has a longer half-life, Cecropin or PGLa?
Cecropin half-life: Minutes (proteolytic). PGLa half-life: Minutes (proteolytic).
Can you stack Cecropin and PGLa?
Cecropin and PGLa are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.