Side-by-Side Comparison · 2026

Cecropin vs Polyphemusin

Cecropin vs Polyphemusin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Cecropin
Antimicrobial Peptide

Cecropins are a family of antimicrobial peptides first discovered in 1980 by Hans Boman in the silkmoth Hyalophora cecropia. Cecropin A was the first AMP characterized from an insect, establishing the paradigm of innate immune peptide-based defense....

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Polyphemusin
Antimicrobial Peptide

Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a disulfide-bridged beta-hairpin with potent antimicrobial activity....

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Key Parameters
Parameter Cecropin Polyphemusin
Category Antimicrobial Peptide Antimicrobial Peptide
Research Preclinical Preclinical
Half-Life Minutes (proteolytic) Hours (disulfide stabilized)
Typical Dose N/A N/A
Frequency N/A N/A
Route Research only Research only
FDA Status Not approved Not approved

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Frequently Asked Questions
What is the difference between Cecropin and Polyphemusin?
Cecropin: Cecropins are a family of antimicrobial peptides first discovered in 1980 by Hans Boman in the silkmoth Hyalophora cecropia. Cecropin A was the first AMP characterized from an insect, establishing the... Polyphemusin: Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe crab (Limulus polyphemus). Structurally similar to tachyplesin from the Japanese horseshoe crab, it adopts a dis...
Which has a longer half-life, Cecropin or Polyphemusin?
Cecropin half-life: Minutes (proteolytic). Polyphemusin half-life: Hours (disulfide stabilized).
Can you stack Cecropin and Polyphemusin?
Cecropin and Polyphemusin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.